|
November 16 | November 17 | November 18 | List (PDF) |
| Monday, November 15 |
| | 9:15— |
REGISTRATION OPENS, POSTER MOUNTING |
| | 10:00— |
10th Annual Meeting of the Japan Endotoxin Society: |
| |
| |
15:30—16:15 |
Special Lecture |
| |
|
Hiroyuki HIRASAWA |
| |
|
Clinical Aspect of Hypercytokinemia in Critical Care
—Pathophysiology, Evaluation and Countermeasure— |
| |
16:15—17:05 |
Invited Lecture I |
| |
|
Ernst RIETSCHEL |
| |
|
Chemical constitution and biological activities
of bacteria lipopolysaccharides |
| |
17:05—17:55 |
Invited Lecture II |
| |
|
Jack LEVIN |
| |
|
The clinical significance of endotoxemia |
|
| |
18:00— |
WELCOME PARTY |
November
16 | November 17 | November 18 | List
(PDF) |
| Tuesday, November 16 |
| |
8:00—08:30 |
Continental Breakfast, POSTER VIEWING |
| |
8:20- |
OPENING CEREMONY Takashi Yokochi, Toshikazu Yoshikawa |
| SESSION A — CHEMISTRY AND BIOLOGY OF ENDOTOXIN I |
| |
Moderators:
Shoichi Kusumoto, Ulrich Zähringer |
| 1 |
08:30—08:55 |
Christopher WHITFIELD —Overview |
| |
Evolutionary biology of endotoxin: from genomics to physiology |
| 2 |
08:55—09:20 |
Douglas GOLENBOCK — Overview |
| |
Endotoxin signaling |
| 3 |
09:20—09:40 |
M. Stephen TRENT |
| |
Remodeling of Helicobacter pylori LPS |
| 4 |
09:40—10:00 |
Russell BISHOP |
| |
Structure and function of PagP |
| |
10:00—10:20 |
Break |
| 5 |
10:20—10:40 |
Kiyoshi KAWASAKI |
| |
Lipid A deacylation by PagL: regulation of TLR4 signaling |
| 6 |
10:40—11:00 |
Robert ERNST |
| |
Biological relevance of lipid A variation in Yersinia species |
| 7 |
11:00—11:15 |
Thomas GUTSMANN |
| |
Lipid-mediated resistance of Gram-negative bacteria against pore-forming anti-microbial peptides |
| 8 |
11:15—11:30 |
Rosevelt PARDY |
| |
Molecules from eukaryotic algae possess LPS-like features but inhibit innate responses of mouse macrophages |
| 47 |
11:30—11:40 |
Selected ABSTRACT — Yukari FUJIMOTO |
| |
Synthesis of lipid A and its novel analogues for investigation of the structural and conformational bases for their bioactivity |
| 63 |
11:40—11:50 |
Selected ABSTRACT — Anthony MORAN |
| |
Helicobacter varies LPS antigenic structure to evade surfactant protein D |
| |
12:00—13:00 |
LUNCH
BREAK |
| |
12:00—13:00 (and beyond) |
LUNCH WORKSHOPS |
| |
Room 104A
Molecular, structural and physical bases of cell activation by endotoxin |
| 12:00—12:10 |
Physicochemical characterization and endotoxic activity of
synthetic monophosphoryl analogues of lipid A |
| |
Kent Myers, Klaus Brandenburg |
| 12:10—12:20 |
Physicochemical characterization and biologic activity of lipooligosaccharides
from Neisseria meningitidis |
| |
Susu Zughaier |
| 12:20—12:30 |
A region of MD-2 required for the antagonistic activity of lipid IVA |
| |
M Muroi |
| 12:30—12:40 |
Inhibition of cell activation: Shedding new light on antagonism |
| |
Andra Schromm |
| 12:40 |
OPEN DISCUSSION |
Room 104B
Regulation of endotoxin-dependent and –independent TLR signaling |
| 12:00—12:10 |
Involvement of lipid rafts in lipopolysaccharide-induced
downregulation of surface TLR4 expression in TLR4/MD-2/CD14-CHO cells |
| |
Tsuyoshi Shuto |
| 12:10—12:20 |
The tetraspanins CD37 and CD81 are involved in LPS signaling |
| |
Holger Heine |
| 12:20—12:30 |
P. gingivalis and E. coli LPS differentially activate human gingival
fibroblasts and alter EGF and P2X7 nucleotide receptor expression |
| |
Beatriz Quinchia-Rios |
| 12:30—12:40 |
IL-10 released by concomitant TLR2 stimulation blocks the induction
of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3
in human dendritic cells |
| |
Fabio Re |
| 12:40 |
OPEN DISCUSSION |
|
| |
13:00—14:30 |
POSTER VIEWING (47-147) |
| SESSION B — CHEMISTRY AND BIOLOGY OF ENDOTOXIN II |
| |
Moderators: Kenichi
Tanamoto, Ernst Rietschel |
| 9 |
14:40—15:00 |
Mareike MÜLLER |
| |
Endotoxin: physical requirements for cell activation |
| 10 |
15:00—15:20 |
Kensuke MIYAKE |
| |
Innate immune recognition of LPS by TLR4/MD-2 |
| 11 |
15:20—15:40 |
Theresa GIOANNINI |
| |
Mechanisms of action of endotoxin agonists and antagonists |
| 12 |
15:40—16:00 |
Roman JERALA |
| |
Structural interactions of LPS with MD-2 and neutralizing antagonists |
| |
16:00—16:20 |
BREAK |
| 13 |
16:20—16:40 |
Nicholas GAY |
| |
Structural determinants of Toll signaling: Spaetzle and MD-2 |
| 14 |
16:40—17:00 |
Kate FITZGERALD |
| |
TRIF-related adaptor molecule (TRAM): a central player in LPS signaling |
| 35A |
17:00—17:20 |
Aisling DUNNE |
| |
Mal: processing and post-translational modification |
| 89 |
17:20—17:30 |
Selected ABSTRACT — Jérôme PUGIN |
| |
Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock |
| 96,97 |
17:30—17:40 |
Selected ABSTRACT — Susumu MATSUO |
| |
Molecular and functional dissection of IκB-ζ, an endotoxin-induced transcriptional regulator |
| 100 |
17:40—17:50 |
Selected ABSTRACT — Mya Mya MU |
| |
Inhibition of mitogen and stress-activated protein kinase 1/2 induces mitochondria-mediated apoptotic cell death in lipopolysaccharide-stimulated RAW 264.7 macrophage cells |
November
16 | November 17 | November 18 | List
(PDF) |
| Wednesday, November 17 |
| |
08:00—08:30 |
CONTINENTAL BEAKFAST,
POSTER VIEWING |
| SESSION C — NEGATIVE REGULATION OF ENDOTOXIN ACTIVITY |
| |
Moderators: Takashi Yokochi, Ulrich Seydel |
| 16 |
08:30—08:55 |
Robert MUNFORD — Overview |
| |
Detoxifying endotoxin: time, place and person |
| 17 |
08:55—09:15 |
Patrick RENSEN |
| |
Apolipoproteins modulate inflammatory responses to LPS in rodents and humans: implications for sepsis |
| 18 |
09:15—09:35 |
Richard KITCHENS |
| |
Endogenous apolipoprotein E (apoE) and ATP-binding cassette transporter A1 (ABCA1) promote LPS efflux from macrophages |
| 19 |
09:35—09:55 |
Richard CHABY |
| |
Interactions between LPS and surfactant proteins |
| |
09:55—10:15 |
BREAK |
| 20 |
10:15—10:35 |
Mathias HORNEF |
| |
Toll-like receptor-mediated recognition by intestinal epithelial cells |
| 21 |
10:35—10:55 |
Christopher KARP |
| |
Negative regulation of TLR4 signaling by RP105 |
| 22 |
10:55—11:15 |
Mingfang LU |
| |
Taming the humoral immune response to Gram-negative bacteria |
| 122 |
11:15—11:25 |
Selected ABSTRACT — Katharina BRANDL |
| |
A complex of soluble TLR4 and MD-2 blocks LPS activity in vitro |
| 159 |
11:25—11:35 |
Selected ABSTRACT — Hyun-Ku LEE |
| |
Double-stranded RNA-mediated TLR3 activation is enhanced by CD14 |
| 23 |
11:35—11:55 |
Ralf SCHUMANN |
| |
Non-LPS actions and targets of LBP (LPS binding protein) |
| |
12:00—14:00 |
LUNCH BREAK |
| |
12:10—13:10 |
LUNCHEON
SEMINAR |
| |
|
Co-organized by
Seikagaku Corporation |
| |
“New Developments
in (1,3)- beta-D-Glucan Research.”
 Program [PDF, 20KB]
Abstracts [PDF,
40KB] |
| SESSION D — CHEMISTRY AND BIOLOGY OF OTHER MICROBIAL TARGETS OF INNATE IMMUNITY |
| |
Moderators: Yoshio Kumazawa, Artur Ulmer |
| 24 |
14:00—14:25 |
Kiyoshi TAKEDA — Overview |
| |
Evolution and integration of innate immune recognition systems: the Toll-like receptors |
| 25 |
14:25—14:40 |
Roman DZIARSKI — Overview |
| |
Peptidoglycan recognition and innate immunity |
| 26 |
14:40—15:00 |
Dominique MENGIN-LECREULX |
| |
Bacterial cell wall peptidoglycan: structure, function and metabolism |
| 27 |
15:00—15:20 |
Roy MARIUZZA |
| |
Crystal structure of PGRP domains (± ligand) |
| |
15:20—15:40 |
BREAK |
| 28 |
15:40—16:00 |
Stephen GIRARDIN |
| |
Nod1 and Nod2 are pattern-recognition molecules involved in peptidoglycan recognition |
| 29 |
16:00—16:20 |
Thomas HARTUNG |
| |
Structural and molecular determinants of pro-inflammatory properties of lipoteichoic acids |
| 30 |
16:20—16:40 |
Kasper HOEBE |
| |
CD36 as a sensor of diacylglycerides acting in conjunction with TLR2 and TLR6 |
| 31 |
16:40—17:00 |
Ken-Ichiro SHIBATA |
| |
Structure—activity relationships of bacterial lipopeptides with TLR2/heterodimers |
| |
17:00—18:30 |
BUSINESS MEETING
BANQUET |
|
November
16 | November 17 | November 18 | List
(PDF) |
| Thursday, November 18 |
| |
08:00—08:30 |
CONTINENTAL BEAKFAST,
POSTER VIEWING |
| SESSION E — BASIC AND CLINICAL CONCEPTS IN INNATE IMMUNITY I |
| |
Moderators: Haruhiko Takada, Alan Cross |
| 32 |
08:30—08:55 |
Jean-Marc REICHHART — Overview |
| |
Evolution and integration of innate immune systems from fruit flies to man: lessons and questions |
| 33 |
08:55—09:15 |
Neal SILVERMAN |
| |
Monomeric and polymeric Gram-negative peptidoglycan, but not purified LPS, activate Drosophila IMD pathway |
| 34 |
09:15—09:35 |
Teizo FUJITA |
| |
Pattern recognition and lectin-complement pathway |
| |
09:35—09:45 |
Selected ABSTRACT — Sandra S.H. TAN |
| |
Recombinant C-reactive protein from the horseshoe crab is a
potent pathogen recognition receptor (PRR) |
| |
09:45—10:05 |
BREAK |
| 36 |
10:05—10:25 |
Akihiko YOSHIMURA |
| |
SOCS1 and SOCS3 are central regulators for macrophage and dendritic
cell activation |
| 37 |
10:25—10:45 |
Jean-Marc CAVAILLON |
| |
Reprogramming of circulatory cells in sepsis and SIRS |
| 38 |
10:45—11:05 |
Tsukasa SEYA |
| |
TLRs and their adaptors in adjuvant immunotherapy for cancer |
| 15 |
11:05—11:25 |
Kenya HONDA |
| |
Identification of a cytosolic complex involving
MyD88 and the transcription factor IRF-7 that triggers Toll-like receptor-induced
IFN-α/β gene expression |
| 188 |
11:25—11:35 |
Selected ABSTRACT — Minou ADIB-CONQUY |
| |
Cross-talk between Nod1, Nod2 and Toll-like receptors (TLRs) for cytokine production by macrophages in response to Gram-positive bacteria |
| 208 |
11:35—11:45 |
Selected ABSTRACT — Ofer LEVY |
| |
Human newborn blood monocytes demonstrate low TNF-α but high IL-6 responses to an array of Toll-like receptor ligands: role of a low-molecular weight plasma inhibitor of TNF-α release |
| 196 |
11:45—11:55 |
Selected ABSTRACT — Basel AL-RAMADI |
| |
CD154 is essential for protection against Gram-negative Salmonella infections |
| 184 |
11:55—12:05 |
Selected ABSTRACT — Dawn BOWISH |
| |
The host defence peptide LL-37 is a multi-functional immunomodulator which interacts directly with the effector cells of the innate immune response |
| |
12:05—13:00 |
LUNCH
BREAK |
| |
12:15—13:15
(and beyond) |
LUNCH WORKSHOPS |
| |
Room 104A
Host responses to infection: Innate immune mechanisms |
| 12:15—12:25 |
The acute phase protein haptoglobin prevents
hemoglobin-induced dispersion of LPS aggregates and suppresses the hemoglobin-mediated
enhancement of cellular activation by LPS |
| |
Christian Alexander |
| 12:25—12:35 |
CD14 and TLR2 Pattern Recognition Receptors differentially modulate host
response to S. pneumoniae in vivo and in vitro |
| |
Regina Landmann |
| 12:35—12:45 |
Pattern recognition receptor deficiency compromises host resistance
to pneumonic Tularemia |
| |
Tim Sellati |
| 12:45—12:55 |
A non-tolerizing dose of Gram-negative bacterial lipopolysaccharide
primes anti-bacterial host defenses: a model for the role of endotoxin
in innate immunity |
| |
Alan Cross |
| 12:55 |
OPEN DISCUSSION |
Room 104B
Structural bases of interactions between acylated bacterial compounds (endotoxin
and beyond) and host peptides/proteins |
| 12:15—12:25 |
Structure/function studies on endotoxin-neutralizing
and antibacterial peptides derived from NK-lysin |
| |
Jörg
Andrä |
| 12:25—12:35 |
Biophysical characterization of the interaction of Limulus polyphemus
endotoxin-neutralizing protein (ENP) with LPS |
| |
Klaus Brandenburg |
| 12:35—12:45 |
MARCKS-LPS interaction in epithelial cells and its effect on actin filament
depolymerization |
| |
Roman Jerala |
| 12:45—12:55 |
Structure-activity relationship of signaling by synthetic lipopeptides
through TLR2/TLR6 and TLR2/TLR1 heterodimers |
| |
Artur Ulmer |
| 12:55 |
OPEN DISCUSSION |
|
| |
13:00—14:30 |
POSTER VIEWING (148-232) |
| SESSION F — BASIC AND CLINICAL CONCEPTS IN INNATE IMMUNITY II |
| |
Moderators:
Hiroshi Fukui, , Jérôme Pugin |
| 39 |
14:35—15:00 |
Stefanie VOGEL — Overview |
| |
Genetic bases of host responses to endotoxin and resistance to infection |
| 40 |
15:00—15:20 |
Moshe ARDITI |
| |
TLRs and Atherosclerosis |
| 41 |
15:20—15:40 |
Mathias CHAMAILLARD |
| |
Nod2: from human genetics to pathophysiology of Crohn's disease |
| 42 |
15:40—16:00 |
Hans FISCHER |
| |
Toll-like receptor 4 discriminates pathogens from commensals through pathogen specific recognition receptors |
| |
16:00—16:20 |
BREAK |
| 43 |
16:20—16:40 |
Anne PUEL |
| |
Inherited human IRAK-4 deficiency and infectious diseases |
| 44 |
16:40—17:00 |
David PERSING |
| |
Short- and long-term suppression of atopic responses in the airways by TLR-4 agonists |
| 45 |
17:00—17:20 |
Alfred AYALA |
| |
The role and regulation of apoptosis in sepsis |
| 46 |
17:20—17:40 |
Kelly SMITH |
| |
A systems approach to study of sepsis and innate immunity |
| |
17:40 |
CLOSING REMARKS; ADJOURNMENT |
